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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TSC2
All Species:
9.7
Human Site:
S1259
Identified Species:
21.33
UniProt:
P49815
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49815
NP_000539.2
1807
200608
S1259
S
L
S
V
P
A
A
S
T
A
K
P
P
P
L
Chimpanzee
Pan troglodytes
XP_523477
1803
200189
S1259
S
L
S
V
P
A
A
S
T
A
R
R
P
S
L
Rhesus Macaque
Macaca mulatta
XP_001083256
1807
200600
S1259
S
L
S
V
P
A
A
S
T
A
K
P
P
P
L
Dog
Lupus familis
XP_852047
1813
201226
G1259
S
L
S
V
P
A
A
G
S
A
K
P
P
P
P
Cat
Felis silvestris
Mouse
Mus musculus
Q61037
1814
202053
T1259
I
V
S
A
T
G
C
T
A
K
P
P
T
L
P
Rat
Rattus norvegicus
P49816
1809
201259
G1259
S
L
S
V
P
A
A
G
T
A
K
P
P
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516748
947
107028
H435
A
Y
R
A
R
A
I
H
P
A
K
D
G
W
I
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695912
1128
123244
R616
G
K
P
A
P
I
Q
R
S
N
T
D
S
V
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524177
1847
204101
R1330
E
D
A
Q
S
R
A
R
N
P
V
R
R
V
N
Honey Bee
Apis mellifera
XP_395739
1813
206229
P1262
G
S
P
A
R
P
S
P
S
R
Q
S
S
R
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786931
1947
217345
H1359
D
G
K
Q
S
I
S
H
R
G
L
E
S
D
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
97.9
91.2
N.A.
88.9
91
N.A.
44.1
N.A.
N.A.
35.8
N.A.
29.8
38.2
N.A.
31.1
Protein Similarity:
100
99
99
94.6
N.A.
92.2
93.9
N.A.
48.3
N.A.
N.A.
44.3
N.A.
49.7
58.6
N.A.
48.9
P-Site Identity:
100
80
100
80
N.A.
13.3
86.6
N.A.
20
N.A.
N.A.
6.6
N.A.
6.6
0
N.A.
0
P-Site Similarity:
100
86.6
100
86.6
N.A.
26.6
86.6
N.A.
33.3
N.A.
N.A.
20
N.A.
13.3
20
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
37
0
55
55
0
10
55
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
0
0
0
0
0
0
0
0
0
19
0
10
10
% D
% Glu:
10
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
19
10
0
0
0
10
0
19
0
10
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
19
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
19
10
0
0
0
0
0
0
0
10
% I
% Lys:
0
10
10
0
0
0
0
0
0
10
46
0
0
0
0
% K
% Leu:
0
46
0
0
0
0
0
0
0
0
10
0
0
10
37
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
0
0
10
10
0
0
0
0
10
% N
% Pro:
0
0
19
0
55
10
0
10
10
10
10
46
46
28
19
% P
% Gln:
0
0
0
19
0
0
10
0
0
0
10
0
0
0
0
% Q
% Arg:
0
0
10
0
19
10
0
19
10
10
10
19
10
10
0
% R
% Ser:
46
10
55
0
19
0
19
28
28
0
0
10
28
10
0
% S
% Thr:
0
0
0
0
10
0
0
10
37
0
10
0
10
10
0
% T
% Val:
0
10
0
46
0
0
0
0
0
0
10
0
0
19
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% W
% Tyr:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _